مؤسسة الشرق الأوسط للنشر العلمي
عادةً ما يتم الرد في غضون خمس دقائق
Most recent works emphasize the central role of inflammation in the development of psychiatric diseases with a special interest for adolescent age, due to ongoing developmental changes occurring within different brain regions. In this review, we provide a perspective of the complex interplay between inflammation and brain activity in adolescence under normal circumstances during youth development, possibly shaping its relation with suicidal behavior. Other processes moreover take place during adolescence, such as synaptic pruning and myelination ( both of which happen in the thought), that are vital pro intellectual expansion plus demonstrative development. This results in extensive changes to both the brain and immune system at a time of increased susceptibility to inflammatory reactions. Interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNFα)] pro-inflammatory cytokines target neurotransmitter systems including oxidative stress, altering mood state and cognitive functioning within the TBI patient. Prolonged neuroinflammation has been implicated Chronic neuroinflammation has been implicated across various psychiatric disorders, particularly in cases of depression, which is a critical factor in suicidal tendencies. This review includes the present understanding inflammation of the brain and how it changes the stages of adolescent development. It focuses on biological aspects of how inflammation alters the functioning of the brain, such as microglial activation and oxidative stress, and their possible role in the onset of various psychiatric disorders. It also presents findings on the neural correlates of suicide with regards inflammation research highlighting high levels of inflammation in the blood of adolescents with suicidal thoughts or actions. Therapeutic trends such as possible anti-inflammatory treatment as well as avenues for further work such as time and individualized treatment were also described. In as much as this review sought to present the complexities of inflammation on brain function, it intends to address the aetiology of suicidal behaviour among adolescents so as to advance the current approaches of prevention and intervention’.